HAMMOCK LAB
The Laboratory of Pesticide Biotechnology
1260. Pressly B, Lee RD, Barnych B, Hammock BD, Wulff H. 2021. Identification of the Functional Binding Site for the Convulsant Tetramethylenedisulfotetramine in the Pore of the α2β3γ2 GABA-A Receptor. Molecular Pharmacology. 99(1):78-91. 10.1124/molpharm.120.000090. PMID: 33109687. PMCID: PMC7746976. [Download]
1261. Hashimoto K, Hammock BD. 2021. Reply to Reeves and Dunn: Risk for autism in offspring after maternal glyphosate exposure. Proceedings of the National Academy of Sciences. 118(2):e2016496118. 10.1073/pnas.2016496118. PMID: 33443192. PMCID: PMC7812790. [Download]
1263. Sun C-P, Zhang X-Y, Morisseau C, Hwang SH, Zhang Z-J, Hammock BD, Ma X-C. 2021. Discovery of Soluble Epoxide Hydrolase Inhibitors from Chemical Synthesis and Natural Products. Journal of Medicinal Chemistry. 64(1):184-215. 10.1021/acs.jmedchem.0c01507. PMID: 33369424. PMCID: PMC7942193. [Download]
1264. Hammock BD, McReynolds CB, Wagner K, Buckpitt A, Cortes-Puch I, Croston G, Lee KSS, Yang J, Schmidt WK, Hwang SH. 2021. Movement to the Clinic of Soluble Epoxide Hydrolase Inhibitor EC5026 as an Analgesic for Neuropathic Pain and for Use as a Nonaddictive Opioid Alternative. Journal of Medicinal Chemistry. 10.1021/acs.jmedchem.0c01886. PMCID: PMC7917437. [Download]
1265. Wang Y, Wagner KM, Morisseau C, Hammock BD. 2021. Inhibition of the Soluble Epoxide Hydrolase as an Analgesic Strategy: A Review of Preclinical Evidence. J Pain Res. 2021;14:61-72. PMID: 33488116. PMCID: PMC7814236. https://doi.org/10.2147/JPR.S241893. [Download]
1267. Wang L, Zhao D, Tang L, Li H, Liu Z, Gao J, Edin ML, Zhang H, Zhang K, Chen J, Zhu X, Wang D, Zeldin DC, Hammock BD, Wang J, Huang H. 2021. Soluble epoxide hydrolase deficiency attenuates lipotoxic cardiomyopathy via upregulation of AMPK-mTORC mediated autophagy. Journal of Molecular and Cellular Cardiology. 154:80-91. PMID: 33378686. PMCID: PMC8068623. https://doi.org/10.1016/j.yjmcc.2020.12.013. [Download]
1268. Pressly B, Vasylieva N, Barnych B, Singh V, Singh L, Bruun DA, Hwang SH, Chen Y-J, Fettinger JC, Johnnides S, Lein PJ, Yang J, Hammock BD, Wulff H. 2020. Comparison of the toxicokinetics of the convulsants picrotoxinin and tetramethylenedisulfotetramine (TETS) in mice. Archives of Toxicology. 94(6):1995-2007. 10.1007/s00204-020-02728-z. PMID: 32239239. PMCID: PMC7303059. [Download]
1269. Greite R, Derlin K, Hensen B, Thorenz A, Rong S, Chen R, Hellms S, Jang MS, Bräsen JH, Meier M, Willenberg I, Immenschuh S, Haller H, Luft FC, Panigrahy D, Hwang SH, Hammock BD, Schebb NH, Gueler F. 2020. Early antihypertensive treatment and ischemia-induced acute kidney injury. Am J Physiol Renal Physiol. 319(4):F563-f570. 10.1152/ajprenal.00078.2020. PMCID: PMC7642887. [Download]
1270. Sun C-C, Zhang C-Y, Duan J-X, Guan X-X, Yang H-H, Jiang H-L, Hammock BD, Hwang SH, Zhou Y, Guan C-X, Liu S-K, Zhang J. 2020. PTUPB ameliorates high-fat diet-induced non-alcoholic fatty liver disease via inhibiting NLRP3 inflammasome activation in mice. Biochemical and Biophysical Research Communications. 523(4):1020-1026. https://doi.org/10.1016/j.bbrc.2019.12.131. PMID: 31973813. PMCID: PMC7990110. [Download]
1271. Brighty GJ, Botham RC, Li S, Nelson L, Mortenson DE, Li G, Morisseau C, Wang H, Hammock BD, Sharpless KB, Kelly JW. 2020. Using sulfuramidimidoyl fluorides that undergo sulfur(VI) fluoride exchange for inverse drug discovery. Nat Chem. 12(10):906-913. 10.1038/s41557-020-0530-4. PMID: 32868886. PMCID: PMC7541551. [Download]
1272. Mello A, Hsu MF, Koike S, Chu B, Cheng J, Yang J, Morisseau C, Torok NJ, Hammock BD, Haj FG. 2021. Soluble Epoxide Hydrolase Hepatic Deficiency Ameliorates Alcohol-Associated Liver Disease. Cell Mol Gastroenterol Hepatol. 11(3):815-830. 10.1016/j.jcmgh.2020.10.002. PMID: 33068774. PMCID: PMC7851189. [Download]
1275. Xie M, Yang J, Zhang J, Sherman HL, Zhang Z, Minter LM, Hammock BD, Park Y, Zhang G. 2020. Effects of Linoleic Acid-Rich Diet on Plasma Profiles of Eicosanoids and Development of Colitis in Il-10(-/-) Mice. J Agric Food Chem. 68(29):7641-7647. 10.1021/acs.jafc.0c03024. PMID: 32594738. PMCID: PMC7901524. [Download]
1278. Zhang YF, Sun CC, Duan JX, Yang HH, Zhang CY, Xiong JB, Zhong WJ, Zu C, Guan XX, Jiang HL, Hammock BD, Hwang SH, Zhou Y, Guan CX. 2020. A COX-2/sEH dual inhibitor PTUPB ameliorates cecal ligation and puncture-induced sepsis in mice via anti-inflammation and anti-oxidative stress. Biomed Pharmacother. 126:109907. 10.1016/j.biopha.2020.109907. PMID: 32114358. PMCID: PMC8868492. [Download]
1280. Mo F, Duan S, Jiang X, Yang X, Hou X, Shi W, Carlos CJJ, Liu A, Yin S, Wang W, Yao H, Yu Z, Tang Z, Xie S, Ding Z, Zhao X, Hammock BD, Lu X. 2021. Nanobody-based chimeric antigen receptor T cells designed by CRISPR/Cas9 technology for solid tumor immunotherapy. Signal Transduction and Targeted Therapy. 6(1):80. 10.1038/s41392-021-00462-1. PMID: 33627635. PMCID: PMC7904846. [Download]
1284. Jazebi N, Evans C, Kadaru HS, Kompella D, Fang F, Raji M, Pappolla M, Tang SJ, Chung JM, Hammock BD, Fang X. 2021. HIV-related Neuropathy: Pathophysiology, Treatment, and Challenges. J Neurol Exp Neurosci 7(1): 15-24. doi: 10.17756/jnen.2021-082. PMCID: PMC8896895. [Download]
1285. Jamieson KL, Darwesh AM, Sosnowski DK, Zhang H, Shah S, Zhabyeyev P, Yang J, Hammock BD, Edin ML, Zeldin DC, Oudit GY, Kassiri Z, Seubert JM. 2021. Soluble Epoxide Hydrolase in Aged Female Mice and Human Explanted Hearts Following Ischemic Injury. Int J Mol Sci. 2021 Feb 8;22(4):1691. doi: 10.3390/ijms22041691. PMID: 33567585. PMCID: PMC7915306. [Download]
1286. Singh N, Barnych B, Wagner KM, Wan D, Morisseau C, Hammock BD. 2021. Adrenic Acid-Derived Epoxy Fatty Acids Are Naturally Occurring Lipids and Their Methyl Ester Prodrug Reduces Endoplasmic Reticulum Stress and Inflammatory Pain. ACS Omega 6 (10), 7165-7174. DOI: 10.1021/acsomega.1c00241. PMCID: PMC7970556. [Download]
1287. McReynolds CB, Cortes-Puch I, Ravindran R, Khan IH, Hammock BG, Shih P-aB, Hammock BD, Yang J. 2021. Plasma Linoleate Diols Are Potential Biomarkers for Severe COVID-19 Infections. Frontiers in Physiology. 12(403). 10.3389/fphys.2021.663869. PMID: 33868029. PMCID: PMC8047414. [Download]
1289. Yao L, Cao B, Cheng Q, Cai W, Ye C, Liang J, Liu W, Tan L, Yan M, Li B, He J, Hwang SH, Zhang X, Wang C, Ai D, Hammock BD, Zhu Y. 2019. Inhibition of soluble epoxide hydrolase ameliorates hyperhomocysteinemia-induced hepatic steatosis by enhancing β-oxidation of fatty acid in mice. Am J Physiol Gastrointest Liver Physiol. 316(4):G527-g538. 10.1152/ajpgi.00148.2018. PMID: 30789748. PMCID: PMC6483021. [Download]
1290. Codony S, Calvó-Tusell C, Valverde E, Osuna S, Morisseau C, Loza MI, Brea J, Pérez C, Rodríguez-Franco MI, Pizarro-Delgado J, Corpas R, Griñán-Ferré C, Pallàs M, Sanfeliu C, Vázquez-Carrera M, Hammock BD, Feixas F, Vázquez S. 2021. From the Design to the In Vivo Evaluation of Benzohomoadamantane-Derived Soluble Epoxide Hydrolase Inhibitors for the Treatment of Acute Pancreatitis. Journal of Medicinal Chemistry. 10.1021/acs.jmedchem.0c01601. PMID: 33945278. PMCID: PMC8634379. [Download]
1291. Morisseau C, Kodani SD, Kamita SG, Yang J, Lee KS, Hammock BD. 2021. Relative Importance of Soluble and Microsomal Epoxide Hydrolases for the Hydrolysis of Epoxy-Fatty Acids in Human Tissues. International Journal of Molecular Sciences. 22(9). 10.3390/ijms22094993. PMID: 34066758. PMCID: PMC8125816. [Download]
1293. Mavangira V, Kuhn MJ, Abuelo A, Morisseau C, Hammock BD, Sordillo LM. 2021. Activity of sEH and Oxidant Status during Systemic Bovine Coliform Mastitis. Antioxidants. 10(5). 10.3390/antiox10050812. PMID: 34065244. PMCID: PMC8161397. [Download]
1294. Baek SJ, Hammock BD, Hwang I-K, Li Q, Moustaid-Moussa N, Park Y, Safe S, Suh N, Yi S-S, Zeldin DC, Zhong Q, Bradbury JA, Edin ML, Graves JP, Jung H-Y, Jung Y-H, Kim M-B, Kim W, Lee J, Li H, Moon J-S, Yoo I-D, Yue Y, Lee J-Y, Han H-J. 2021. Natural Products in the Prevention of Metabolic Diseases: Lessons Learned from the 20th KAST Frontier Scientists Workshop. Nutrients. 13(6):1881. PMID: 34072678. PMCID: PMC8227583. [Download]
1295. Jonnalagadda D, Wan D, Chun J, Hammock BD, Kihara Y. 2021. A Soluble Epoxide Hydrolase Inhibitor, 1-TrifluoromethoxyPhenyl-3-(1-Propionylpiperidin-4-yl) Urea, Ameliorates Experimental Autoimmune Encephalomyelitis. Int J Mol Sci. 22(9). 10.3390/ijms22094650. PMID: 33925035. PMCID: PMC8125305. [Download]
1296. Koike S, Hsu MF, Bettaieb A, Chu B, Matsumoto N, Morisseau C, Havel PJ, Huising MO, Hammock BD, Haj FG. 2021. Genetic deficiency or pharmacological inhibition of soluble epoxide hydrolase ameliorates high fat diet-induced pancreatic β-cell dysfunction and loss. Free Radic Biol Med. 10.1016/j.freeradbiomed.2021.05.029. [Download]
1297. Wang S, Ishima T, Qu Y, Shan J, Chang L, Wei Y, Zhang J, Pu Y, Fujita Y, Tan Y, Wang X, Ma L, Wan X, Hammock BD, Hashimoto K. 2021. Ingestion of Faecalibaculum rodentium causes depression-like phenotypes in resilient Ephx2 knock-out mice: A role of brain–gut–microbiota axis via the subdiaphragmatic vagus nerve. Journal of Affective Disorders. 292:565-573. https://doi.org/10.1016/j.jad.2021.06.006. PMID: 34147969. PMCID: PMC8282729. [Download]
1299. Du F, Sun W, Morisseau C, Hammock BD, Bao X, Liu Q, Wang C, Zhang T, Yang H, Zhou J, Xiao W, Liu Z, Chen G. 2021. Discovery of adamantyl urea derivatives as potent soluble epoxide hydrolase inhibitors against lipopolysaccharide-induced sepsis. European Journal of Medicinal Chemistry. 223:113678. https://doi.org/10.1016/j.ejmech.2021.113678. PMID: 34218083. PMCID: PMC8877601. [Download]
1300. Gautheron J, Morisseau C, Chung WK, Zammouri J, Auclair M, Baujat G, Capel E, Moulin C, Wang Y, Yang J, Hammock BD, Cerame B, Phan F, Fève B, Vigouroux C, Andreelli F, Jeru I. 2021. EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescence. eLife. 10:e68445. 10.7554/eLife.68445. PMID: 34342583. PMCID: PMC8331186. [Download]
1301. Ravindran R, McReynolds C, Yang J, Hammock BD, Ikram A, Ali A, Bashir A, Zohra T, Chang WLW, Hartigan-O’Connor DJ, Rashidi HH, Khan IH. 2021. Immune response dynamics in COVID-19 patients to SARS-CoV-2 and other human coronaviruses. PLOS ONE. 16(7):e0254367. 10.1371/journal.pone.0254367. PMID: 34242356. PMCID: PMC8270414. [Download]
1304. Khan MAH, Hwang SH, Barnett SD, Stavniichuk A, Jankiewicz WK, Hammock BD, Imig JD. 2021. Multitarget molecule, PTUPB, to treat diabetic nephropathy in rats. British Journal of Pharmacology. n/a(n/a). https://doi.org/10.1111/bph.15623. PMID: 34255857. PMCID: PMC8863090. [Download]
1305. Tiwari S, Yang J, Morisseau C, Durbin-Johnson B, Hammock BD, Gomes AV. 2021. Ibuprofen alters epoxide hydrolase activity and epoxy-oxylipin metabolites associated with different metabolic pathways in murine livers. Scientific reports. 11(1):7042. 10.1038/s41598-021-86284-1. PMID: 33782432. PMCID: PMC8007717. [Download]
1306. Yang Y, Xu X, Wu H, Yang J, Chen J, Morisseau C, Hammock BD, Bettaieb A, Zhao L. 2021. Differential Effects of 17,18-EEQ and 19,20-EDP Combined with Soluble Epoxide Hydrolase Inhibitor t-TUCB on Diet-Induced Obesity in Mice. Int J Mol Sci. 22(15). 10.3390/ijms22158267. PMID: 34361032. PMCID: PMC8347952. [Download]
1307. Sun C-P, Zhang X-Y, Zhou J-J, Huo X-K, Yu Z-L, Morisseau C, Hammock BD, Ma X-C. 2021. Inhibition of sEH via stabilizing the level of EETs alleviated Alzheimer's disease through GSK3β signaling pathway. Food and Chemical Toxicology. 156:112516. https://doi.org/10.1016/j.fct.2021.112516. PMID: 34411643. PMCID: PMC8889936. [Download]
1308. McReynolds CB, Yang J, Guedes A, Morisseau C, Garcia R, Knych H, Tearney C, Hamamoto B, Hwang SH, Wagner K, Hammock BD. 2021. Species Differences in Metabolism of Soluble Epoxide Hydrolase Inhibitor, EC1728, Highlight the Importance of Clinically Relevant Screening Mechanisms in Drug Development. Molecules. 26(16). 10.3390/molecules26165034. PMID: 34443621. PMCID: PMC8399023. [Download]
1309. Fang Y, Johnson H, Anderl JL, Muchamuel T, McMinn D, Morisseau C, Hammock BD, Kirk C, Wang J. 2021. Role of epoxide hydrolases and cytochrome P450s on metabolism of KZR-616, a first-in-class selective inhibitor of the immunoproteasome. Drug Metabolism and Disposition.DMD-AR-2020-000307. 10.1124/dmd.120.000307. PMID: 34234005. [Download]
1310. Du F, Cao R, Chen L, Sun J, Shi Y, Fu Y, Hammock BD, Zheng Z, Liu Z, Chen G. 2021. Structure-guided discovery of potent and oral soluble epoxide hydrolase inhibitors for the treatment of neuropathic pain. Acta Pharmaceutica Sinica B. https://doi.org/10.1016/j.apsb.2021.09.018. PMID: 35530144. PMCID: PMC9072249. [Download]
1311. Deng J, Yang H, Haak VM, Yang J, Kipper FC, Barksdale C, Hwang SH, Gartung A, Bielenberg DR, Subbian S, Ho K-K, Ye X, Fan D, Sun Y, Hammock BD, Panigrahy D. 2021. Eicosanoid regulation of debris-stimulated metastasis. Proceedings of the National Academy of Sciences. 118(41):e2107771118. 10.1073/pnas.2107771118. PMID: 34607951. PMCID: PMC8521662. [Download]
1313. Thai PN, Ren L, Xu W, Overton J, Timofeyev V, Nader CE, Haddad M, Yang J, Gomes AV, Hammock BD, Chiamvimonvat N, Sirish P. 2021. Chronic Diclofenac Exposure Increases Mitochondrial Oxidative Stress, Inflammatory Mediators, and Cardiac Dysfunction. Cardiovasc Drugs Ther. 10.1007/s10557-021-07253-4. PMID: 34499283. PMCID: PMC8904649. [Download]
1314. Bergmann CB, Hammock BD, Wan D, Gogolla F, Goetzman H, Caldwell CC, Supp DM. 2021. TPPU treatment of burned mice dampens inflammation and generation of bioactive DHET which impairs neutrophil function. Scientific reports. 11(1):16555. 10.1038/s41598-021-96014-2. PMID: 34400718. PMCID: PMC8368302. [R35 ES030443, P42 ES004699]. EH [Download]
1317. Wilt S, Kodani S, Valencia L, Hudson PK, Sanchez S, Quintana T, Morisseau C, Hammock BD, Kandasamy R, Pecic S. 2021. Further exploration of the structure-activity relationship of dual soluble epoxide hydrolase/fatty acid amide hydrolase inhibitors. Bioorganic & Medicinal Chemistry. 51:116507. https://doi.org/10.1016/j.bmc.2021.116507. PMID: 34794001. PMCID: PMC8900675. [Download]
1316. Gowler PRW, Turnbull J, Shahtaheri M, Gohir S, Kelly T, McReynolds C, Jun Y, Jha RR, Fernandes GS, Zhang W, Doherty M, Walsh DA, Bruce HD, Valdes AM, Barrett DA, Chapman V. 2021. Clinical and preclinical evidence for roles of soluble epoxide hydrolase in osteoarthritis knee pain. Arthritis Rheumatol. 10.1002/art.42000. PMID: 34672113. PMCID: PMC8957539. [Download]
1318. Singh N, Vik A, Lybrand DB, Morisseau C, Hammock BD. 2021. New Alkoxy- Analogues of Epoxyeicosatrienoic Acids Attenuate Cisplatin Nephrotoxicity In Vitro via Reduction of Mitochondrial Dysfunction, Oxidative Stress, Mitogen-Activated Protein Kinase Signaling, and Caspase Activation. Chemical Research in Toxicology. 10.1021/acs.chemrestox.1c00347. PMID: 34817988. PMCID: PMC8853703. [Download]
1319. Xu J, Qiu X, Yu G, Ly M, Yang J, Silva RM, Zhang X, Yu M, Wang Y, Hammock B, Pinkerton KE, Zhao D. 2022. Soluble epoxide hydrolase inhibitor can protect the femoral head against tobacco smoke exposure-induced osteonecrosis in spontaneously hypertensive rats. Toxicology. 465:153045. PMID: 34801612. PMCID: PMC9484547. https://doi.org/10.1016/j.tox.2021.153045. [Download]
1321. Martín-López J, Codony S, Bartra C, Morisseau C, Loza MI, Sanfeliu C, Hammock BD, Brea J, Vázquez S. 2021. 2-(Piperidin-4-yl)acetamides as Potent Inhibitors of Soluble Epoxide Hydrolase with Anti-Inflammatory Activity. Pharmaceuticals. 14(12). 10.3390/ph14121323. PMID: 34959721; PMCID: PMC8703317. [Download]
1322. Wagner KM, Yang J, Morisseau C, Hammock BD. 2021. Soluble Epoxide Hydrolase Deletion Limits High-Fat Diet-Induced Inflammation. Frontiers in Pharmacology. 12:3373. PMID: 34975481; PMCID: PMC8719166. [Download]
1323. Zhao Z, Zhang C, Lin J, Zheng L, Li H, Qi X, Huo H, Lou X, Hammock BD, Hwang SH, Bao Y, Luo M. 2021. COX-2/sEH Dual Inhibitor PTUPB Alleviates CCl4-Induced Liver Fibrosis and Portal Hypertension. Frontiers in Medicine. 8. 10.3389/fmed.2021.761517. PMID: 35004731; PMCID: PMC8734593. [Download]
1325. Jankiewicz WK, Barnett SD, Stavniichuk A, Hwang SH, Hammock BD, Belayet JB, Khan AH, Imig JD. 2021. Dual sEH/COX-2 Inhibition Using PTUPB—A Promising Approach to Antiangiogenesis-Induced Nephrotoxicity. Frontiers in Pharmacology. 12. 10.3389/fphar.2021.744776. PMID: 34955823; PMCID: PMC8695932. [Download]
1326. Wan D, Morisseau C, Hammock BD, Yang J. 2022. A Fast and Selective Approach for Profiling Vicinal Diols Using Liquid Chromatography-Post Column Derivatization-Double Precursor Ion Scanning Mass Spectrometry. Molecules. 27(1):283. PMID: 35011515; PMCID: PMC8747065. [Download]
1331. Ulu A, Velazquez JV, Burr A, Sveiven SN, Yang J, Bravo C, Hammock BD, Nordgren TM. 2022. Sex-Specific Differences in Resolution of Airway Inflammation in Fat-1 Transgenic Mice Following Repetitive Agricultural Dust Exposure. Front Pharmacol. 2022 Jan 13;12:785193. doi: 10.3389/fphar.2021.785193. PMID: 35095496; PMCID: PMC8793679. [Download]
1332. Sun CP, Zhou JJ, Yu ZL, Huo XK, Zhang J, Morisseau C, Hammock BD, Ma XC. 2022. Kurarinone alleviated Parkinson's disease via stabilization of epoxyeicosatrienoic acids in animal model. Proc Natl Acad Sci U S A. 2022 Mar 1;119(9):e2118818119. doi: 10.1073/pnas.2118818119. PMID: 35217618. PMCID: PMC8892522. [Download]
1333. Leuillier M, Duflot T, Ménoret S, Messaoudi H, Djerada Z, Groussard D, Denis RGP, Chevalier L, Karoui A, Panthu B, Thiébaut P-A, Schmitz-Afonso I, Nobis S, Campart C, Henry T, Sautreuil C, Luquet SH, Beseme O, Féliu C, Peyret H, Nicol L, Henry J-P, Renet S, Mulder P, Wan D, Tesson L, Heslan J-M, Duché A, Jacques S, Ziegler F, Brunel V, Rautureau GJP, Monteil C, do Rego J-L, do Rego J-C, Afonso C, Hammock B, Madec A-M, Pinet F, Richard V, Anegon I, Guignabert C, Morisseau C, Bellien J. 2022. CRISPR/Cas9-mediated Inactivation of the Phosphatase Activity of Soluble Epoxide Hydrolase Prevents Obesity and Cardiac Ischemic Injury. Journal of Advanced Research. https://doi.org/10.1016/j.jare.2022.03.004 [Download]
1334. Codony S, Pont C, Griñán-Ferré C, Di Pede-Mattatelli A, Calvó-Tusell C, Feixas F, Osuna S, Jarné-Ferrer J, Naldi M, Bartolini M, Loza MI, Brea J, Pérez B, Bartra C, Sanfeliu C, Juárez-Jiménez J, Morisseau C, Hammock BD, Pallàs M, Vázquez S, Muñoz-Torrero D. 2022. Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer’s Disease. Journal of Medicinal Chemistry. 65(6):4909-4925. 10.1021/acs.jmedchem.1c02150. PMID: 35271276. PMCID: PMC8958510. [Download]
1336. Bergmann Christian B, McReynolds Cindy B, Wan D, Singh N, Goetzman H, Caldwell Charles C, Supp Dorothy M, Hammock Bruce D. 2022. sEH-derived metabolites of linoleic acid drive pathologic inflammation while impairing key innate immune cell function in burn injury. Proceedings of the National Academy of Sciences. 119(13):e2120691119. 10.1073/pnas.2120691119. PMID: 35312372. PMCID: PMC9060469. [Download]
1337. Abdalla HB, Napimoga MH, Teixeira JM, Trindade-da-Silva CA, Pieroni VL, Dos Santos Araújo FSM, Hammock BD, Clemente-Napimoga JT. 2022. Soluble epoxide hydrolase inhibition avoid formalin-induced inflammatory hyperalgesia in the temporomandibular joint. Inflammopharmacology. 2022 Mar 18. doi: 10.1007/s10787-022-00965-5. Epub ahead of print. PMID: 35303234. [Download]
1338. Zhang C, Li W, Li X, Wan D, Mack S, Zhang J, Wagner K, Wang C, Tan B, Chen J, Wu CW, Tsuji K, Takeuchi M, Chen Z, Hammock BD, Pinkerton KE, Yang J. 2022. Novel aerosol treatment of airway hyper-reactivity and inflammation in a murine model of asthma with a soluble epoxide hydrolase inhibitor. PLoS One. 2022 Apr 20;17(4):e0266608. doi: 10.1371/journal.pone.0266608. PMID: 35443010; PMCID: PMC9020733. [Download]
1339. Singh N, Li D, McReynolds CB, Morisseau C, Hammock BD. 2022. Improved ELISA for linoleate-derived diols in human plasma utilizing a polyHRP-based secondary tracer. Analytical Methods. 10.1039/D2AY00272H. PMID: 35481804. PMCID: PMC9116231. [Download]
1340. Edin ML, Lih FB, Hammock BD, Thomson S, Zeldin DC, Bishop-Bailey D. 2020. Vascular Lipidomic Profiling of Potential Endogenous Fatty Acid PPAR Ligands Reveals the Coronary Artery as Major Producer of CYP450-Derived Epoxy Fatty Acids. Cells. 9(5):1096. PMID: 32365470. PMCID: PMC7290345. [Download]
1341. Montecillo-Aguado M, Tirado-Rodriguez B, AntonioAndres G, Morales-Martinez M, Tong Z, Yang J, Hammock BD, Hernandez-Pando R, Huerta-Yepez S. 2022. Omega-6 Polyunsaturated Fatty Acids Enhance Tumor Aggressiveness in Experimental Lung Cancer Model: Important Role of Oxylipins. Int. J. Mol. Sci. 2022, 23, 6179. https://doi.org/10.3390/ ijms23116179. PMID: 35682855. PMCID: PMC9181584. [Download]
1343. Matsumoto N, Singh N, Lee KS, Barnych B, Morisseau C, Hammock BD. 2022. The epoxy fatty acid pathway enhances cAMP in mammalian cells through multiple mechanisms. Prostaglandins & Other Lipid Mediators. 162:106662. https://doi.org/10.1016/j.prostaglandins.2022.106662. [Download]
1346. Burmistrov V, Morisseau C, Babkov DA, Golubeva T, Pitushkin D, Sokolova EV, Vasipov V, Kuznetsov Y, Bazhenov SV, Novoyatlova US, Bondarev NA, Manukhov IV, Osipova V, Berberova N, Spasov AA, Butov GM, Hammock BD. 2022. Anti-Inflammatory Activity of Soluble Epoxide Hydrolase Inhibitors Based on Selenoureas Bearing an Adamantane Moiety. International Journal of Molecular Sciences. 2022, 23, 10710. https://www.mdpi.com/1422-0067/23/18/10710#cite. [Download]
1348. Kyaw TS, Sukmak M, Nahok K, Sharma A, Silsirivanit A, Lert-Itthiporn W, Sansurin N, Senthong V, Anutrakulchai S, Sangkhamanon S, Pinlaor S, Selmi C, Cha’on U, Hammock BD. Monosodium glutamate consumption reduces the renal excretion of trimethylamine N-oxide and the abundance of Akkermansia muciniphila in the gut. 2022. Biochemical and Biophysical Research Communications. 630:158-166. PMID: 36155062. 10.1016/j.bbrc.2022.09.038. [Download]
1349. Nguyen N, Morisseau C, Li D, Yang J, Lam E, Woodside DB, Hammock BD, Shih PB. Soluble Epoxide Hydrolase Is Associated with Postprandial Anxiety Decrease in Healthy Adult Women. 2022. International Journal of Molecular Sciences. 23(19), 11798. https://doi.org/10.3390/ijms231911798. [Download]
1350. Codony S, Entrena JM, Calvó-Tusell C, Jora, B, González-Cano R, Osuna S, Corpas R, Morisseau C, Pérez B, Barniol-Xicota M, Griñán-Ferré Christian, Pérez C, Rodríguez-Franco MI, Martínez AL, Loza MI, Pallàs M, Verhelst S, Sanfeliu C, Feixas F, Hammock BD; Brea J, Cobos EJ, Vázquez S. Synthesis, In Vitro Profiling, and In Vivo Evaluation of Benzohomoadamantane-Based Ureas for Visceral Pain: A New Indication for Soluble Epoxide Hydrolase Inhibitors. 2022. Journal of Medicinal Chemistry. 65, 20, 13660-13680. PMID: 36222708. PMCID: PMC9620236. https://doi.org/10.1021/acs.jmedchem.2c00515. [Download]
1353. Hammock BD, Li QX. John Edward Casida. 22 December 1929-30 June 2018. 2022. The Royal Society of Chemistry. https://doi.org/10.1098/rsbm.2022.0016. [Download]
1355. Zhang J, Luan Z, Huo X, Zhang M, Morisseau C, Sun C, Hammock BD, Ma X. Direct targeting of sEH with alisol B alleviated the apoptosis, inflammation, and oxidative stress in cisplatin-induced acute kidney injury. 2023. International Journal of Biological Sciences. 19(1): 294-310. doi:10.7150/ijbs.78097. PMID: 36594097. PMCID: PMC9760444. https://www.ijbs.com/v19p0294.htm. [Download]
1358. Nguyen PT, Nguyen HM, Wagner KM, Stewart RG, Singh V, Thapa P, Chen YJ, Lillya MW, Ton AT, Kondo R, Ghetti A, Pennington MW, Hammock BD, Griffith TN, Sack JT, Wulff H, Yarov-Yarovoy V. Computational design of peptides to target Nav1.7 channel with high potency and selectivity for the treatment of pain. 2022. BioRxiv. 500925. PMID: 28115115. https://doi.org/10.1101/2022.07.21.500925. [Download]
1359. Naeem Z, Zukunft S, Günther S, Liebner S, Weigert A, Hammock BD, Frömel T, Fleming I. Role of the soluble epoxide hydrolase in the hair follicle stem cell homeostasis and hair growth. 2022. Pflügers Archiv - European Journal of Physiology. 474, 1021–1035. PMID: 35648219. PMCID: PMC9393123. https://doi.org/10.1007/s00424-022-02709-4. [Download]
1361. Yang JC, Xu P, Ning S, Wasielewski LJ, Admoat H, Hwang SH, Morisseau C, Gleave M, Corey E, Gao AC, Lara PN, Evans CP, Hammock BD, Liu C. Novel inhibition of AKR1C3 and androgen receptor axis by PTUPB synergizes enzalutamide treatment in advanced prostate cancer. Oncogene. 2023 Jan 3. https://doi.org/10.1038/s41388-022-02566-6. Epub ahead of print. PMID: 36596844. [Download]
1362. Wang W, Wang Y, Yang J, Wagner KM, Hwang SH, Cheng J, Singh N, Edwards P, Morisseau C, Zhang G, Panigrahy D, Hammock BD. Aflatoxin B1 exposure disrupts the intestinal immune function via a soluble epoxide hydrolase-dependent mechanism. 2023. Ecotoxicology and Environmental Safety. 249:114417. PMID: 36525946. PMCID: PMC9879385. https://doi.org/10.1016/j.ecoenv.2022.114417. [Download]
1363. Angelia J, Weng X, Solomatov A, Chin C, Fernandez A, Hudson PK, Morisseau C, Hammock BD, Kandasamy R, Pecic S. Structure-activity relationship studies of benzothiazole-phenyl analogs as multi-target ligands to alleviate pain without affecting normal behavior. Prostaglandins and Other Lipid Mediators. 2023. 164:106702. PMID: 36529320. PMCID: PMC9879382. https://doi.org/10.1016/j.prostaglandins.2022.106702. [Download]
1364. Dover M, Moseley T, Biskaduros A, Paulchakrabarti M, Hwang S, Hammock BD, Choudhury B, Kaczor-Urbanowicz KE, Urbanowicz A, Morselli M, Dang J, Pellegrini M, Paul K, Bentolila LA, Fiala M. Polyunsaturated Fatty Acids Mend Macrophage Transcriptome, Glycome, and Phenotype in the Patients with Neurodegenerative Diseases, Including Alzheimer’s Disease. Journal of Alzheimer’s Disease. 2023. 91(1):245-261. PMID: 36373322. DOI: 10.3233/JAD-220764. [Download]
1365. Atone J, Wagner K, Koike S, Yang J, Hwang SH, Hammock BD. Inhibition of Soluble Epoxide Hydrolase Reduces Paraquat Neurotoxicity in Rodents. Environmental Toxicology and Pharmacology. 2023. 104070. ISSN 1382-6689. PMID: 36682504. DOI: https://doi.org/10.1016/j.etap.2023.104070. [Download]
1366. Chen Y, Chen L, Xu H, Cao R, Morisseau C, Zhang M, Shi Y, Hammock BD, Wang J, Zhuang J, Liu Z, Chen G. Structure-Directed Discovery of Potent Soluble Epoxide Hydrolase Inhibitors for the Treatment of Inflammatory Diseases. Journal of Medicinal Chemistry. 2023. PMID: 36689364. DOI: https://doi.org/10.1021/acs.jmedchem.2c01996. [Download]
1367. Burmistrov V, Morisseau C, Pitushkin D, Fayzullin RR, Karlov D, Vernigora A, Kuznetsov Y, Abbas SMH, Butov GM, Hammock BD. Ureas derived from camphor and fenchone reveal enantiomeric preference of human soluble epoxide hydrolase. Results in Chemistry. 2022. DOI: https://doi.org/10.1016/j.rechem.2022.100653. [Download]
1368. Burmistrov VV, Morisseau C, Shkineva TK, Danilov DV, Gladkikh B, Butov GM, Fayzullin RR, Dutova TY, Hammock BD, Dalinger IL. Adamantyl-ureas with pyrazoles substituted by fluoroalkanes as soluble epoxide hydrolase inhibitors. Journal of Fluorine Chemistry. 2023. 266: 110087. DOI: https://doi.org/10.1016/j.jfluchem.2023.110087. [Download]
1369. Abdalla HB, Alvarez C, Wu Y, Rojas P, Hammock BD, Maddipati KR, Trinidade-da-Silva CA, Soares MQS, Clemente-Napimoga JT, Kantarci A, Napimoga MH, Van Dyke TE. Soluble epoxide hydrolase inhibition enhances Specialized Pro-resolving Lipid Mediator production and promotes macrophage plasticity. British Journal of Pharmacology. 2022. PMID: 36508312. https://doi.org/10.1111/bph.16009. [Download]
1370. Luo A, Wu Z, Li S, McReynolds CB, Wang D, Liu H, Huang C, He T, Zhang X, Wang Y, Liu C, Hammock BD, Hashimoto K, Yang C. The soluble epoxide hydrolase inhibitor TPPU improves comorbidity of chronic pain and depression via the AHR and TSPO signaling. Journal of Translational Medicine. 2023. 21:71. PMID: 36732752. PMCID: PMC9896784. DOI: https://doi.org/10.1186/s12967-023-03917-x. [Download]
1373. Richter FC, Friedrich M, Kampschulte N, Piletic K, Alsaleh G, Zummach R, Hecker J, Pohin M, Ilott N, Guschina I, Wideman SK, Johnson E, Borsa M, Hahn P, Morisseau C, Hammock BD, Schipper HS, Edwards CM, Zechner R, Siegmund B, Weidinger C, Schebb NH, Powrie F, Simon AK. Adipocyte autophagy limits gut inflammation by controlling oxylipin and IL-10. The EMBO Journal. 2023. E112202. PMID: 36795015. DOI: https://doi.org/10.15252/embj.2022112202. [Download]
1374. Takeshita AA, Hammock BD, Wagner KM. Soluble epoxide hydrolase inhibition alleviates chemotherapy induced neuropathic pain. Frontiers in Pain Research. 2023. PMID: 36700145. PMCID: PMC9868926. https://doi.org/10.3389/fpain.2022.1100524. [Download]
1376. Wang W, Wagner KM, Wang Y, Singh N, Yang J, He Q, Morisseau C, Hammock BD. Soluble epoxide hydrolase contributes to cell senescence and ER stress in aging mice colon. International Journal of Molecular Sciences. 2023, 24(5), 4570. PMID: 36901999. PMCID: PMC10003560. https://doi.org/10.3390/ijms24054570. [Download]
1377. Zhang J, Zhang M, Huo X-K, Ning J, Yu Z-L, Morisseau C, Sun C-P, Hammock BD, Ma X-C. Macrophage Inactivation by Small Molecule Wedelolactone via Targeting sEH for the Treatment of LPS-Induced Acute Lung Injury. American Chemical Society. 2023. https://doi.org/10.1021/acscentsci.2c01424. [Download]
1381. He Q, McCoy MR, Yang H, Lin M, Cui X, Zhao X, Morisseau C, Li D, Hammock BD. Mix-and-Read Nanobody-Based Sandwich Homogeneous Split-Luciferase Assay for the Rapid Detection of Human Soluble Epoxide Hydrolase. Analytical Chemistry. 2023. PMID: 36972550. https://doi.org/10.1021/acs.analchem.3c00079. [Download]
1382. Vázquez J, Ginex T, Herrero A, Morisseau C, Hammock BD, Luque Garriga FJ. Screening and Biological Evaluation of Soluble Epoxide Hydrolase Inhibitors: Assessing the Role of Hydrophobicity in the Pharmacophore-Guided Search of Novel Hits. Journal of Chemical Information and Modeling. 2023. PMID: 37141492. https://pubs.acs.org/action/showCitFormats?doi=10.1021/acs.jcim.3c00301&ref=pdf. [Download]
1383. El-Sheikh ESA, Li D, Hamed I, Ashour MB, Hammock BD. Residue Analysis and Risk Exposure Assessment of Multiple Pesticides in Tomato and Strawberry and Their Products from Markets. Foods. 2023, 12(10), 1936. DOI: https://doi.org/10.3390/foods12101936 [Download]
1384. Basting RT, Napimoga MH, Trindade Silva CA, Abdalla HB, Durso BC, Barboza Martins LH, de Abreu Cavalcanti H, Hammock BD, Clemente-Napimoga JT. Soluble epoxide hydrolase inhibitor blockage microglial cell activation in subnucleus caudalis in a persistent model of arthritis. International Immunopharmacology. 120(2023)110320. https://doi.org/10.1016/j.intimp.2023.110320. [Download]
1385. Shen Q, Yang J, Zamora D, Horowitz M, Faurot KR, MacIntosh BA, Mann JD, Hammock BD, Ramsden CE, Taha AY. Associations between Plasma Lipid Mediators and Chronic Daily Headache Outcomes in Patients Randomized to a Low Linoleic Acid Diet with or without Added Omega-3 Fatty Acids. Metabolites. 2023, 13, 690. https://doi.org/10.3390/metabo13060690. [Download]
1386. Pan S, Karey E, Nieves-Cintron M, Chen Y-J, Hwang SH, Hammock BD, Pinkerton KE, Chen C-Y. Effects of chronic secondhand smoke exposure on cardiovascular regulation and the role of soluble epoxide hydrolase in mice. Frontiers in Physiology. 2023. 14:1185744. DOI: https://doi.org/10.3389/fphys.2023.1185744. [Download]
1387. Wang W, Wang Y, Wagner KM, Lee RD, Hwang SH, Morisseau C, Wulff H, Hammock BD. Aflatoxin B1 Increases Soluble Epoxide Hydrolase in the Brain and Induces Neuroinflammation and Dopaminergic Neurotoxicity. International Journal of Molecular Sciences. 2023. 24(12), 9938. DOI: https://doi.org/10.3390/ijms24129938. [Download]
1389. McReynolds C, Hammock BD, Morisseau C. Regulatory lipid vicinal diols counteract the biological activity of epoxy fatty acids and can act as biomarkers and mechanisms for disease progression. Pharmacology & Therapeutics. 2023. 248:108454. PMID: 37268114. DOI: https://doi.org/10.1016/j.pharmthera.2023.108454. [Download]
1390. Dai Y, Dong J, Wu Y, Zhu M, Xiong W, Li H, Zhao Y, Hammock BD, Zhu X. Enhancement of the liver’s neuroprotective role ameliorates traumatic brain injury pathology. Proceedings of the National Academy of Sciences. 2023, 120 (26) e2301360120. PMID: 37339206. DOI: https://doi.org/10.1073/pnas.2301360120. [Download]
1391. Oh YT, Yang J, Morisseau C, He Q, Hammock BD, Youn JH. Effects of Individual Circulating FFAs on Plasma and Hepatic FFA Epoxides, Diols, and Epoxide-Diol Ratios as Indices of Soluble Epoxide Hydrolase Activity. International Journal of Molecular Sciences. 2023, 24(13), 10760. DOI: https://doi.org/10.3390/ijms241310760. [Download]
1393. Zhang J, Zhang W, Morisseau C, Zhang M, Dong H, Zhu Q, Huo X, Sun C, Hammock BD, Ma X. Genetic deletion or pharmacological inhibition of soluble epoxide hydrolase attenuated particulate matter 2.5 exposure mediated lung injury. Journal of Hazardous Materials. 2023:131890. DOI: https://doi.org/10.1016/j.jhazmat.2023.131890 [Download]
1394. Zamiri K, Kesari S, Paul K, Hwang SH, Hammock BD, Kaczor-Urbanowicz KE, Urbanowicz A, Gao L, Whitelegge J, Fiala M. Therapy of autoimmune inflammation in sporadic amyotrophic lateral sclerosis: Dimethyl fumarate and H-151 downregulate inflammatory cytokines in the cGAS-STING pathway. The FASEB Journal. 2023. 37: 8. PMID: 37436778. DOI: https://doi.org/10.1096/fj.202300573R. [Download]
1398. He Q, McCoy MR, Qi M, Morisseau C, Yang H, Xu C, Shey R, Goodman MC, Zhao S, Hammock BD. The Generation of a Nanobody-Based ELISA for Human Microsomal Epoxide Hydrolase. Int J Mol Sci. 2023 Sep 28;24(19). doi: 10.3390/ijms241914698 [Download]
1399. Yang H, Qi M, He Q, Hwang SH, Yang J, McCoy M, Morisseau C, Zhao S, Hammock BD. Quantification of soluble epoxide hydrolase inhibitors in experimental and clinical samples using the nanobody-based ELISA. J Pharm Anal. 2023 Sep;13(9):1013-1023. doi: 10.1016/j.jpha.2023.05.006 [Download]
1400. Peyman M, Barroso E, Turcu AL, Estrany F Jr, Smith D, Jurado-Aguilar J, Rada P, Morisseau C, Hammock BD, Valverde ÁM, Palomer X, Galdeano C, Vázquez S, Vázquez-Carrera M. Soluble epoxide hydrolase-targeting PROTAC activates AMPK and inhibits endoplasmic reticulum stress. Biomed Pharmacother. 2023 Dec;168:115667. doi: 10.1016/j.biopha.2023.115667 [Download]
1401. Ravindran R, Kang H, McReynolds C, Sanghar GK, Chang WLW, Ramasamy S, Kolloli A, Kumar R, Subbian S, Hammock BD, Hartigan-O'Connor DJ, Ikram A, Haczku A, Khan IH. Dynamics of temporal immune responses in nonhuman primates and humans immunized with COVID-19 vaccines. PLoS One. 2023;18(10):e0287377. doi: 10.1371/journal.pone.0287377 [Download]
1403. Warner JB, Hardesty JE, Song YL, Floyd AT, Deng Z, Jebet A, He L, Zhang X, McClain CJ, Hammock BD, Warner DR, Kirpich IA. Hepatic Transcriptome and Its Regulation Following Soluble Epoxide Hydrolase Inhibition in Alcohol-Associated Liver Disease. Am J Pathol. 2024 Jan;194(1):71-84. doi: 10.1016/j.ajpath.2023.09.016 [Download]
1409. Kulkarni R, Mehta R, Goswami SK, Hammock BD, Morisseau C, Hwang SH, Mallappa O, Azeemuddin MM, Rafiq M, S N M. Neuroprotective effect of herbal extracts inhibiting soluble epoxide hydrolase (sEH) and cyclooxygenase (COX) against chemotherapy-induced cognitive impairment in mice. Biochem Biophys Res Commun. 2023 Jul 30;667:64-72. doi: 10.1016/j.bbrc.2023.05.008 [Download]
1410. Kim D, Horimatsu T, Ogbi M, Goo B, Shi H, Veerapaneni P, Chouhaita R, Moses M, Prasad R, Benson TW, Harb R, Aboud G, Seller H, Haigh S, Fulton DJ, Csányi G, Huo Y, Long X, Coffey P, Lee R, Guha A, Zeldin D, Hwang SH, Hammock BD, Weintraub NL, Kim HW. Hepatocyte-specific disruption of soluble epoxide hydrolase attenuates abdominal aortic aneurysm formation: novel role of the liver in aneurysm pathogenesis. bioRxiv. 2023 Jul 11:2023.07.10.548127. doi: 10.1101/2023.07.10.548127 [Download]
1411. Hrithrik TH, Lee DH, Singh N, Vik A, Hammock BD, Kim Y. Insect immune resolution with EpOME/DiHOME and its dysregulation by their analogs leading to pathogen hypersensitivity. bioRxiv. 2023 Jul 7:2023.07.07.548078. doi: 10.1101/2023.07.07.548078 [Download]
1413. Wang Y, Morisseau C, Takamura A, Wan D, Li D, Sidoli S, Yang J, Wolan DW, Hammock BD, Kitamura S. PROTAC-Mediated Selective Degradation of Cytosolic Soluble Epoxide Hydrolase Enhances ER Stress Reduction. ACS Chem Biol. 2023 Apr 21;18(4):884-896. doi: 10.1021/acschembio.3c00017 [Download]
1416. Trindade-da-Silva CA, Yang J, Fonseca F, Pham H, Napimoga MH, Abdalla HB, Aver G, De Oliveira MJA, Hammock BD, Clemente-Napimoga JT. Eicosanoid profiles in an arthritis model: Effects of a soluble epoxide hydrolase inhibitor. Biochim Biophys Acta Mol Cell Biol Lipids. 2024 Mar;1869(2):159432. doi: 10.1016/j.bbalip.2023.159432 [Download]
1417. Pu Y, Cheng R, Zhang Q, Huang T, Lu C, Tang Z, Zhong Y, Wu L, Hammock BD, Hashimoto K, Luo Y, Liu Y. Role of soluble epoxide hydrolase in the abnormal activation of fibroblast-like synoviocytes from patients with rheumatoid arthritis. Clin Immunol. 2023 Dec;257:109850. doi: 10.1016/j.clim.2023.109850 [Download]
1418. Oh YT, Yang J, Stefanovski D, Hammock B, Youn JH. Determinants of Meal-Induced Changes in Circulating FFA Epoxides, Diols, and Diol-to-Epoxide Ratios as Indices of Soluble Epoxide Hydrolase Activity. Int J Mol Sci. 2023 Dec 11;24(24). doi: 10.3390/ijms242417351 [Download]
1420. Wang W, Wang Y, Yang J, Wagner KM, Hwang SH, Cheng J, Singh N, Edwards P, Morisseau C, Zhang G, Panigrahy D, Hammock BD. Aflatoxin B(1) exposure disrupts the intestinal immune function via a soluble epoxide hydrolase-mediated manner. Ecotoxicol Environ Saf. 2023 Jan 1;249:114417. doi: 10.1016/j.ecoenv.2022.114417 [Download]
1421. Naeem Z, Zukunft S, Huard A, Hu J, Hammock BD, Weigert A, Frömel T, Fleming I. Role of the soluble epoxide hydrolase in keratinocyte proliferation and sensitivity of skin to inflammatory stimuli. Biomed Pharmacother. 2024 Jan 9;171:116127. doi: 10.1016/j.biopha.2024.116127 [Download]
1422. Abdalla HB, Puhl L, Rivas CA, Wu YC, Rojas P, Trindade-da-Silva CA, Hammock BD, Maddipati KR, Soares MQS, Clemente-Napimoga JT, Kantarci A, Napimoga MH, Van Dyke TE. Modulating the sEH/EETs Axis Restrains Specialized Proresolving Mediator Impairment and Regulates T Cell Imbalance in Experimental Periodontitis. J Immunol. 2024 Feb 1;212(3):433-445. doi: 10.4049/jimmunol.2300650. [Download]
1424. Duan JX, Guan XX, Cheng W, Deng DD, Chen P, Liu C, Zhou Y, Hammock BD, Yang HH. COX-2/sEH-Mediated Macrophage Activation Is a Target for Pulmonary Protection in Mouse Models of Chronic Obstructive Pulmonary Disease. Lab Invest. 2023 Dec 27;104(3):100319. doi: 10.1016/j.labinv.2023.100319. [Download]
1428. Kelly AG, Wang W, Rothenberger E, Yang J, Gilligan MM, Kipper FC, Attaya A, Gartung A, Hwang SH, Gillespie MJ, Bayer RL, Quinlivan KM, Torres KL, Huang S, Mitsiades N, Yang H, Hammock BD, Panigrahy D. Enhancing cancer immunotherapy via inhibition of soluble epoxide hydrolase. Proc Natl Acad Sci U S A. 2024 Feb 13;121(7):e2314085121. doi: 10.1073/pnas.2314085121 [Download]
1431. Chen Y, Sun J, Tong H, Wang J, Cao R, Xu H, Chen L, Morisseau C, Zhang M, Shi Y, Han C, Zhuang J, Jing Y, Liu Z, Hammock BD, Chen G. Design and Synthesis of Dual-Targeting Inhibitors of sEH and HDAC6 for the Treatment of Neuropathic Pain and Lipopolysaccharide-Induced Mortality. J Med Chem. 2024 Feb 8;67(3):2095-2117. doi: 10.1021/acs.jmedchem.3c02006. [Download]
1432. Burmistrov VV, Morisseau C, Danilov DV, Gladkikh BP, D'yachenko VS, Zefirov NA, Zefirova ON, Butov GM, Hammock BD. Fluorine and chlorine substituted adamantyl-urea as molecular tools for inhibition of human soluble epoxide hydrolase with picomolar efficacy. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2274797. doi: 10.1080/14756366.2023.2274797. [Download]
1433. Steffan BN, Calise D, Park SC, Niu M, Yang J, Hammock BD, Jones M, Steele C, Keller NP. Loss of the mammalian G-protein coupled receptor, G2A, modulates severity of invasive pulmonary aspergillosis. Front Immunol. 2023;14:1173544. doi: 10.3389/fimmu.2023.1173544. [Download]
1438. Hossain Hrithik MT, Shahmohammadi N, Jin G, Lee DH, Singh N, Vik A, Hammock BD, Kim Y. Insect immune resolution with EpOME/DiHOME and its dysregulation by their analogs leading to pathogen hypersensitivity. Insect Biochem Mol Biol. 2024 Mar 15;168:104104. doi: 10.1016/j.ibmb.2024.104104. [Download]
1442. Edin ML, Gruzdev A, Graves JP, Lih FB, Morisseau C, Ward JM, Hammock BD, Bosio CM, Zeldin DC. Effects of sEH inhibition on the eicosanoid and cytokine storms in SARS-CoV-2-infected mice. FASEB J. 2024 May 31;38(10):e23692. doi: 10.1096/fj.202302202RR [Download]
1443. Angelia J, Duong L, Yun F, Mesic A, Yuan C, Carr D, Gunari S, Hudson PK, Morisseau C, Hammock BD, Kandasamy R, Pecic S. Quinolinyl-based multitarget-directed ligands with soluble epoxide hydrolase and fatty acid amide hydrolase inhibitory activities: Synthetic studies and pharmacological evaluations. Heliyon. 2024 Jun 15;10(11):e32262. doi: 10.1016/j.heliyon.2024.e32262 [Download]
1446. Xu H, Chen Y, Tong H, Chen L, Morisseau C, Zhou Z, Zhuang J, Song C, Cai P, Liu Z, Hammock BD, Chen G. Design and Synthesis of sEH/HDAC6 Dual-Targeting Inhibitors for the Treatment of Inflammatory Pain. J Med Chem. 2024 Jul 21. doi: 10.1021/acs.jmedchem.4c00847 [Download]
1449. Sule RO, Morisseau C, Yang J, Hammock BD, Gomes AV. Triazine herbicide prometryn alters epoxide hydrolase activity and increases cytochrome P450 metabolites in murine livers via lipidomic profiling. Sci Rep. 2024 Aug 19;14(1):19135. doi: 10.1038/s41598-024-69557-3. [Download]
1450. Sukmak M, Kyaw TS, Nahok K, Sharma A, Silsirivanit A, Lert-Itthiporn W, Japrung D, Pinlaor S, Anutrakulchai S, Selmi C, Slupsky CM, Hammock BD, Cha'on U. Urinary metabolic profile and its predictive indexes after MSG consumption in rat. PLoS One. 2024 Sep 3;19(9):e0309728. doi: 10.1371/journal.pone.0309728. [Download]
1452. Schmidt WK, Cortés-Puch I, McReynolds CB, Croston GE, Hwang SH, Yang J, Pedersen TL, Wagner KM, Pham TT, Hunt T, Hammock BD. Randomized, double-blind, phase 1a single-ascending dose and food effect studies assessing safety and pharmacokinetics of EC5026 in healthy volunteers. Clin Transl Sci. 2024 Sep;17(9):e70033. doi: 10.1111/cts.70033. [Download]
1453. Vargas BDS, Vargas BSF, Clemente-Napimoga JT, Hammock BD, Abdalla HB, Van Dyke TE, Napimoga MH. Soluble epoxide hydrolase inhibition impairs triggering receptor expressed on myeloid cells-1 in periodontal tissue. J Periodontal Res. 2024 Sep 29. doi: 10.1111/jre.13350. [Download]
1454. White TD, Almutairi A, Gai-Tusing Y, Stephenson DJ, Stephenson BD, Chalfant CE, Lei X, Lu B, Hammock BD, DiLorenzo TP, Ramanadham S. Differential lipid signaling from CD4+ and CD8+ T cells contributes to type 1 diabetes development. Front Immunol. 2024 Sep 18;15:1444639. doi: 10.3389/fimmu.2024.1444639. [Download]
1456. Babkov D, Eliseeva N, Adzhienko K, Bagmetova V, Danilov D, McReynolds CB, Morisseau C, Hammock BD, Burmistrov V. Preclinical Evaluation of Soluble Epoxide Hydrolase Inhibitor AMHDU against Neuropathic Pain. Int J Mol Sci. 2024 Aug 14;25(16):8841. doi: 10.3390/ijms25168841. [Download]